Substrate: Connexin 43 (Intercellular channel)
Seq-ID: P08050 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-1791070   ZO1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
gap junction channel activity,
PDZ domain binding		 connexon complex,
Golgi-associated vesicle membrane,
early endosome,
integral to plasma membrane,
lysosome,
fascia adherens,
mitochondrial outer membrane,
endoplasmic reticulum membrane,
multivesicular body,
membrane raft		 positive regulation of protein catabolic process,
ATP transport,
response to pH,
negative regulation of cell proliferation,
apoptosis,
vascular transport,
gap junction assembly,
protein oligomerization,
cell-cell signaling,
neuron projection morphogenesis,
regulation of calcium ion transport,
response to peptide hormone stimulus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 247 KDRVKGRSDPYHATTGPLSPS SRC 11514593
LTP
0.22
 - -
0.51
 --
S 255 DPYHATTGPLSPSKDCGSPKY MAPK3 8631994
LTP
0.22
 MOD_ProDKin_1
 - -
0.40
 --
S 255 DPYHATTGPLSPSKDCGSPKY MAPK1 9535909
LTP
0.22
 MOD_ProDKin_1
 - -
0.40
 --
S 255 DPYHATTGPLSPSKDCGSPKY MAPK7 12637502
LTP
0.22
 MOD_ProDKin_1
 - -
0.40
 --
Y 265 SPSKDCGSPKYAYFNGCSSPT SRC 11514593
LTP
0.09
 - -
0.26
 --
S 279 NGCSSPTAPLSPMSPPGYKLV MAPK3 8631994
LTP
0.15
 MOD_ProDKin_1
 - -
0.45
 --
S 279 NGCSSPTAPLSPMSPPGYKLV MAPK1 9535909
LTP
0.15
 MOD_ProDKin_1
 - -
0.45
 --
S 279 NGCSSPTAPLSPMSPPGYKLV - 12637502
LTP
0.15
 MOD_ProDKin_1
 - -
0.45
 --
S 279 NGCSSPTAPLSPMSPPGYKLV MAPK1 15843167
LTP
0.15
 MOD_ProDKin_1
 - -
0.45
 --
S 279 NGCSSPTAPLSPMSPPGYKLV MAPK3 15843167
LTP
0.15
 MOD_ProDKin_1
 - -
0.45
 --
S 282 SSPTAPLSPMSPPGYKLVTGD MAPK3 8631994
LTP
0.98
 MOD_ProDKin_1
 - -
0.57
 --
S 282 SSPTAPLSPMSPPGYKLVTGD MAPK1 9535909
LTP
0.98
 MOD_ProDKin_1
 - -
0.57
 --
S 282 SSPTAPLSPMSPPGYKLVTGD - 12637502
LTP
0.98
 MOD_ProDKin_1
 - -
0.57
 --
S 282 SSPTAPLSPMSPPGYKLVTGD MAPK1 15843167
LTP
0.98
 MOD_ProDKin_1
 - -
0.57
 --
S 282 SSPTAPLSPMSPPGYKLVTGD MAPK3 15843167
LTP
0.98
 MOD_ProDKin_1
 - -
0.57
 --
S 325 AEQNRMGQAGSTISNSHAQPF CK1_delta 12270943
LTP
0.15
 MOD_CK1_1
 - -
0.75
 --
S 328 NRMGQAGSTISNSHAQPFDFP CK1_delta 12270943
LTP
1.00
 MOD_CK1_1
 - -
0.75
 --
S 330 MGQAGSTISNSHAQPFDFPDD CK1_delta 12270943
LTP
0.22
 MOD_CK1_1
 - -
0.76
 --
S 368 IVDQRPSSRASSRASSRPRPD PKC_group 10871288
LTP
0.97
 - -
0.89
 --

Substrate: Connexin 43 (Intercellular channel)
Seq-ID: P17302 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-3088474   ZO1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ion transmembrane transporter activity,
signal transducer activity		 connexon complex,
Golgi-associated vesicle membrane,
integral to plasma membrane,
membrane raft		 muscle contraction,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
gap junction assembly,
cell-cell signaling
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 247 KDRVKGKSDPYHATSGALSPA - 18083107
HTP
0.17
 - -
0.40
 - low
S 255 DPYHATSGALSPAKDCGSQKY - 15605363
LTP
0.95
 - -
0.29
 - low
S 262 GALSPAKDCGSQKYAYFNGCS - 15605363
LTP
0.70
 - -
0.18
 - low
S 279 NGCSSPTAPLSPMSPPGYKLV - 15605363
LTP
0.15
 - -
0.44
 - low
S 282 SSPTAPLSPMSPPGYKLVTGD - 15605363
LTP
0.97
 - -
0.56
 - low
Y 313 KQASEQNWANYSAEQNRMGQA - 18083107
HTP
0.05
 - -
0.62
 - low
S 368 IVDQRPSSRASSRASSRPRPD PKC_epsilon 15534005
LTP
0.96
 - -
0.88
 - low

Substrate: Connexin 43 (Intercellular channel)
Seq-ID: P23242 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-1895242   ZO1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
gap junction channel activity,
receptor binding		 cytosol,
integral to membrane		 limb bud formation,
skeletal muscle tissue regeneration,
adult heart development,
apoptosis,
epithelial cell maturation,
regulation of heart contraction,
in utero embryonic development,
cell-cell signaling,
heart looping,
neuron migration,
negative regulation of gene expression,
blood vessel morphogenesis,
positive regulation of striated muscle tissue development,
positive regulation of gene expression
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 306 SSCRNYNKQASEQNWANYSAE - 17114649
HTP
0.27
 - Connexin43
0.51
 --
S 314 QASEQNWANYSAEQNRMGQAG - 17114649
HTP
0.06
 - -
0.64
 --
S 325 AEQNRMGQAGSTISNSHAQPF - 16882687
LTP
0.16
 - -
0.74
 --
T 326 EQNRMGQAGSTISNSHAQPFD - 17114649
HTP
0.04
 - -
0.74
 --
S 328 NRMGQAGSTISNSHAQPFDFP - 16882687
LTP
1.00
 - -
0.74
 --
S 328 NRMGQAGSTISNSHAQPFDFP - 17114649
HTP
1.00
 - -
0.74
 --
S 330 MGQAGSTISNSHAQPFDFPDD - 16882687
LTP
0.19
 - -
0.75
 --
S 330 MGQAGSTISNSHAQPFDFPDD - 17114649
HTP
0.19
 - -
0.75
 --

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